If you have Gana , Bhakoot and also Nadi dosha then it means that your guna milan score must be close to 10 Guna , which is very less than 18 that is considered minimum for marriage. Marriage should be considered only if the above dosha get cancelled in horoscope matching. The priciples of cancellation of the above dosha are many. You will need help from a astrology expert who will guide you through this if you are a novice on this subject. But yes cancellations are very much there and if cancellations take place then marital life will be happy and successful.