Hi,
In my humble understanding, as Lagna Lord Jupiter/Guru-dev is not subject to Kendradipathya Dosha. But then, Jupiter/Guru-dev being closely conjunct to (11th &) 12th lord of Vyaya/Losses Saturn/Shani-dev is a cause for concern… more so for it is an indication of atrocities on weak/feeble and/or innocent lives in the past life (Gou-Hathya and/or Brahmana-Hatya Dosha). This conjunction also seems to be affecting marital relatioship and hence restricting happiness from marriage – although you might have had a love marriage.
Thereafter, Jupiter/Guru-dev is Vakra or Retrograde and being posited in the Lunar Constellation of Uttarashada Nakshatra, ruled by 6th lord of Roga-Sthana and activating Sun/Ravi is not a good sign. Incidentally, Mercury/Budha (who is also the Rashi depositor) and Moon/Chandra are also posited in the Lunar Constellation of Kritika Nakshatra, ruled by Sun/Ravi are activated. They are close to each other and don’t necessarily seem to be in sync with each other… I’m inclined to think Moon/Chandra, in-turn mind seems to be strong and Mercury/Budha, in-turn intelligence is not able to keep pace – it probably contributes to some quirkiness or eccentricity in your nature/outlook.
Lastly, it also looks like you are susceptible to envy, evil-eye, black-magic and other such spells. From a Vedic/Dharmic remedy point of view, it might not be a bad idea for you to consider appropriate remedial action for Gou-Hathya and/or Brahmana-Hatya Dosha.
Take care…