There is something wrong with his horoscope the details of which we will send you if you come through paid services. He has the 4th and 9th houses the weakest in his charts. What these houses signify can be found from the internet or read my blog navagrahastro.blogspot.in
Please read the articles on my blog which will give you an idea. The ill effects are similar to what you have written like being in a depressed state, lack of happiness, ill luck in most activities etc.