From a classical Vedic astrology perspective, when both partners belong to the Madhya Nadi, it traditionally forms Madhya nadi dosha, which is considered significant in Kundli Milan, especially with respect to health compatibility and progeny. The boy being born in Pushya Nakshatra (2nd pada) and the girl in Anuradha Nakshatra (3rd pada) places both in the same Nadi group, thereby creating this dosha at the surface level. However, Vedic astrology does not rely solely on Nadi classification; deeper principles must be examined before arriving at a conclusion.

In your case, the presence of Paad Vedha becomes very important. Paad Vedha refers to the interaction between the specific quarters (padas) of the nakshatras. When certain padas are involved, the dosha is not merely neutralized but can indicate a complete Nadi Dosha condition, meaning that the standard point-based cancellation rules of Guna Milan are insufficient to fully judge compatibility. This highlights the need for deeper chart-level analysis rather than relying only on Ashta Koota matching.

Because Nadi Dosha is primarily associated with progeny and genetic compatibility, classical texts recommend examining Beeja Sphuta (for the male) and Kshetra Sphuta (for the female). These are precise mathematical combinations derived from planetary longitudes—especially involving Jupiter, Venus, Moon, and Lagna—to assess fertility potential and the ability to conceive healthy offspring. If both Beeja and Kshetra Sphuta are strong and well-placed, the adverse effects of Nadi Dosha can be significantly mitigated.

Therefore, while Madhya Nadi Dosha is present and Paad Vedha makes it more serious, it is not a final verdict against the match. A thorough analysis of Beeja–Kshetra strength, Navamsa chart, and overall planetary harmony is essential to determine the true prospects of marriage and progeny before making any decision.